Hafez, H. M.; Elshanawany, A. A.; Abdelaziz, L. M.; Mohram, M. S. published an article in 2015, the title of the article was Stability indicating HPLC method for drugs indicated for helicobacter pylori-associated ulcers.Quality Control of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole And the article contains the following content:
Triple therapy regimen that comprises a proton pump inhibitor likes Omeprazole, antibiotics like Doxycycline and Tinidazole can be used for treatment of peptic ulceration which is caused by H. pylori. A validated HPLC method was developed as a stability-indicating HPLC method for these drugs and its impurities. New method overcame interference between Doxycycline and its epimer on achiral column by using a chiral mobile phase. The method was performed on Phenomenex BDS HYPERSIL C18 5 μm 100A (250×4.6 mm) and the mobile phase consisted of (1S)-(+)-Campher-10-sulfonic acid (0.01M) and Edetate disodium (0.001M) (pH=4.5) Acetonitrile which pumped at a flow rate 1.2 mL/min in gradient manner at 40°C. 20 μl of drugs sample solutions were monitored at wavelength 310 nm. Tinidazole, Doxycycline and Omeprazole and Trio capsule bulk powders were stressed under different conditions in forced degradation studies. Method validation was developed following the recommendations for anal. method validation of International Conference on Harmonization (ICH) and Food and Drug Administration (FDA) organizations. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Quality Control of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole
The Article related to helicobacter ulcer omeprazole doxycycline tinidazole stability hplc, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Quality Control of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem