Berzas Nevado, Juan Jose; Castaneda Penalvo, Gregorio; Rodriguez Dorado, Rosa M.; Rodriguez Robledo, Virginia published an article in 2013, the title of the article was Study of controlled degradation processes and electrophoretic behaviour of omeprazole and its main degradation products using diode-array and ESI-IT-MS detection.Safety of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole And the article contains the following content:
This paper provides chem. information of controlled degradation processes on omeprazole, and its main degradation products in aqueous solutions, using CE as the anal. technique. Both diode-array and ESI-IT-MS were employed as detectors to generate anal. data of the drugs studied. This information could be used to determine potential impurities for pharmaceuticals of omeprazole because it may influence not only the therapeutic efficacy but also the safety of active pharmaceutical ingredients. For this purpose, a new capillary zone electrophoresis method using diode-array detection for the simultaneous determination of omeprazole and its main degradation products was developed. Some different less aggressive degradation processes were studied, the fastest of which was found to be that of omeprazole in aqueous solutions exposed to UV light (254 nm). Using a background electrolyte (10 mM phosphate buffer, pH 12) the analytes were determined in < 6 min. Electrophoretic behavior using an optical detector revealed the presence of 7 products under the different exptl. conditions used. More anal. chem. information was obtained on omeprazole degradation products using direct infusion electrospray ionization-mass spectrometry operating in neg. ion mode [M - H]-, and even some chem. structures of omeprazole degradation products were proposed. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Safety of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole
The Article related to omeprazole degradation determination capillary zone electrophoresis impurity, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Safety of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem