Li, Zhicheng; Kong, Xiaobo; Mai, Wenpeng; Sun, Gangchun; Zhao, Shizhao published an article in 2014, the title of the article was Synthesis of esomeprazole through asymmetric oxidation.Related Products of 73590-85-9 And the article contains the following content:
N,N’-dicyclohexyl-d-tartaric diamide 2a and N,N’-di-[(R)-indan]-d-tartaric diamide 2b were prepared through the reaction of diethyl-d-tartrate with cyclohexylamine and (R)-(-)-1-aminoindan, resp. The two compounds coordinated with iso-Pr titanate (Ti(O-iPr)4), were used as catalyst in the asym. oxidation of pyrmetazol 3 with cumene hydroperoxide (CHP) as oxidant. The results revealed that both the catalytic systems derived from ligand 2a and 2b with Ti(O-iPr)4 showed good catalytic activity and enantioselectivity in the synthesis of esomeprazole. Under the optimized conditions, the yield reached 91%, 91% and the enantio excess (ee) was up to 87%, 89%. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Related Products of 73590-85-9
The Article related to asym oxidation esomeprazole synthesis, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Related Products of 73590-85-9
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem