On September 30, 1983, Kashik, T. V.; Ponomareva, S. M.; Abramova, N. D.; Skvortsova, G. G. published an article.Computed Properties of 5709-67-1 The title of the article was Effect of meso-substituents on NH-acidity of benzimidazoles. And the article contained the following:
The pK2 values of I (R = Me, Et, H, Ph, OEt, COMe, SMe, SCH:CH2, Cl, NO2) decreased in the order stated, ranging from 26.43 to 18.75 in MeCN at 20°. A linear correlation with σm constants of R was obtained, and the following 2-parameter equation was obtained: pKa = 25.58-9.83σI – 3.86σC, where σI and σC are inductive and conjugation substituent constants The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Computed Properties of 5709-67-1
The Article related to benzimidazole acidity lfer, Physical Organic Chemistry: Acid-Base, Tautomerism, and Other Equilibrium Studies and other aspects.Computed Properties of 5709-67-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem