On August 20, 2013, Song, Wei-guo; Zhang, Xiang-min; Zhang, Xiao-pan; Xu, Wen-fang published an article.Related Products of 73590-85-9 The title of the article was Synthesis of esomeprazole sodium. And the article contained the following:
Esomeprazole was the first optical isomer proton pump inhibitor, and its sodium salt was applied to the patients who are in need of PPI but not capable of oral dosing. At present, there were three methods to synthesize esomeprazole such as omeprazole racemic resolution, omeprazole sulfide complexes asym. catalytic oxidation and biochem. oxidation However, the omeprazole racemic resolution was limited industrially due to its high cost and low yield. The aim of this study was to propose a modified asym. oxidation method to prepare esomeprazole for industrialized production Compared with the traditional method, this new method had three advantages. Firstly, the (1S, 2S)-(-)-1,2-diaminocyclohexane D-tartrate was used as chiral ligands, which avoided the addition of organic alkali in the traditional route. Secondly, cobalt naphthenate was applied as the catalyst to solve the problem of water-contacting over traditional titanium catalyst. Lastly, sodium peroxide was not only the oxidant to lower the cost of asym. oxidizing the omeprazole sulfide compounds but also the source of sodium for no more addition of other sodium source. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Related Products of 73590-85-9
The Article related to esomeprazole sodium synthesis, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Related Products of 73590-85-9
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem