Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 33543-78-1, name is Ethyl 1H-imidazole-2-carboxylate, A new synthetic method of this compound is introduced below., COA of Formula: C6H8N2O2
The ethyl 1-(4-chloro-1-oxo-2-indanyl)-imidazole-2-carboxylate can be prepared as in Example 1 for the preparation of ethyl 1-(5-fluoro-1-oxo-2-indanyl)imidazole-2-carboxylate but starting with 2.8 g of ethyl imidazole-2-carboxylate, 0.6 g of 80percent sodium hydride, 6.4 g of 2-bromo-4-chloro-1-indanone and a total of 80 ml of anhydrous dimethylformamide. After silica gel chromatography with a dichloromethane-ethyl acetate mixture (80-20 by volume), 1.85 g of ethyl 1-(4-chloro-1-oxo-2-indanyl)imidazole-2-carboxylate are obtained Rf=0.3, thin-layer chromatography on silica gel; solvent: dichloromethane-ethyl acetate (80-20 by[volume)]. The 2-bromo-4-chloro-1-indanone can be prepared in the following manner:
The synthetic route of 33543-78-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Rhone-Poulenc Rorer S.A.; US5677306; (1997); A;,
Imidazole – Wikipedia,
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