On September 30, 2015, Dong, Qian; Peng, Xia; Wang, Wen; Dai, Yang; Zhao, Weili; Ai, Jing; Dong, Xiaochun published an article.Computed Properties of 5709-67-1 The title of the article was Design and synthesis of 5-aminopyrazole and 5-aminotriazole derivatives as fibroblast growth factor receptor inhibitors. And the article contained the following:
Fibroblast growth factor receptor (FGFR) is a promising therapeutic target for cancer treatment. A series of 5-aminopyrazole and 5-amino-1,2,3-triazole derivatives were designed as FGFR inhibitors based on the docking mode of Debio1347 within the FGFR kinase domain. The inhibitory effects on FGFR2 kinase and the antitumor activities against human gastric cancer SNU16 cell lines were evaluated. Furthermore, the preliminary structure-activity relationships (SAR) were discussed. The results demonstrated that several compounds presented good potency against FGFR2 kinase. 1-(5-Amino-1-(2-methyl-1H-benzo[d]imidazol-6-yl)-1H-pyrazol-4-yl)-1-(1H-thieno[3,2-b]pyrrol-2-yl) methanone (I) and 1-(5-amino-1-(2-methyl-1H-benzo[d]imidazol-6-yl)-1H-1,2,3-triazol-4-yl)-1-(1H-indol-2-yl)methanone (II) were the most potent with IC50 values of 3.3 and 2.3 nmol路L-1, resp., which were similar to that of Debio1347. Compounds I and II exhibited slightly weaker antitumor activity against SNU16 cell lines than Debio1347 with IC50 value of 77.3 and 155.2 nmol路L-1, resp. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Computed Properties of 5709-67-1
The Article related to aminopyrazole preparation sar fibroblast growth factor receptor inhibitory antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Computed Properties of 5709-67-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem