Acosta-Guzman, Paola; Mahecha-Mahecha, Camilo; Gamba-Sanchez, Diego published an article in 2020, the title of the article was Electrophilic Chlorine from Chlorosulfonium Salts: A Highly Chemoselective Reduction of Sulfoxides.COA of Formula: C17H19N3O2S And the article contains the following content:
A selective late-stage deoxygenation of sulfoxides based on a novel application of chlorosulfonium salts RS+(Cl)R1 (R = Ph, benzyl, benzamidazol-2-yl, pyridin-2-yl, etc.; R1 = Me, Pr, allyl, vinyl, etc.; RR1 = -CH2S(CH2)3-) demonstrates a new process using these species generated in situ from sulfoxides RS(O)R1 as the source of electrophilic chlorine. The use of highly nucleophilic 1,3,5-trimethoxybenzene (TMB) as the reducing agent is described for the first time and applied in the deoxygenation of simple and functionalized sulfoxides. The method is easy to handle, economic, suitable for gram-scale operations, and readily applied for poly-functionalized mols., as demonstrated with more than 45 examples, including com. medicines and analogs. Also results of competition experiments that define the more reactive sulfoxide, and a mechanistic proposal based on substrate and product observations was reported. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).COA of Formula: C17H19N3O2S
The Article related to sulfide preparation chemoselective, sulfoxide deoxidation, chemoselectivity, deoxygenation, sulfides, sulfonium salts, sulfoxides, synthetic methods, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ethers, Sulfides, and The Corresponding Onium Compounds and other aspects.COA of Formula: C17H19N3O2S
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem