On October 1, 2021, Bubyrev, Andrey; Adamchik, Maria; Darin, Dmitry; Kantin, Grigory; Krasavin, Mikhail published an article.COA of Formula: C6H11N3 The title of the article was Metal-Free Three-Component Synthesis of 1,2,3-Triazoline-4-Sulfonamides. And the article contained the following:
A new type of diazo compounds, namely, CH-diazomethane sulfonamides (generated in situ from readily available α-acetyl-α-diazomethane sulfonamides MeC(O)C(=N2)S(O)2NRR1 [R = Me; R1 = Ph, Bn, 4-fluorophenyl; RR1 = -(CH2)4-, -(CH2)2O(CH2)2-]) was employed in a 1,3-dipolar cycloaddition reaction with imines (also formed in situ from primary amines R2NH2 (R2 = n-Bu, cyclopentyl, morpholino, etc.) and aldehydes R3CHO (R3 = cyclopropyl, Ph, pyridin-3-yl, etc.)). The reaction gave hitherto undescribed 1,5-disubstituted 1,2,3-triazolin-4-yl sulfonamides I which were obtained in good to excellent yields and complete trans-diastereoselectivity. Oxidative aromatization of 1,2,3-triazolin-4-yl sulfonamides by manganese(IV) oxide gave nearly quant. yields of 1,2,3-triazol-4-yl sulfonamides II of which only two examples have been reported in the literature. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).COA of Formula: C6H11N3
The Article related to triazolyl sulfonamide preparation, triazolinyl sulfonamide preparation diastereoselective oxidative aromatization, acetyl diazomethane sulfonamide amine aldehyde three component dipolar cycloaddition and other aspects.COA of Formula: C6H11N3
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem