Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Quality Control of 10111-08-7.
Xu, Li-Yan;Chai, Yong-Mei;Li, Cheng-Guo;Chai, Lan-Qin research published 《 Co(II) and Cd(II) complexes with imidazole-2-carboxaldehyde groups: spectroscopic, antibacterial, Hirshfeld surfaces analyses, and TD/DFT calculations》, the research content is summarized as follows. Two complexes [Co(L)2·2CH3OH]2·(NO3)4 (1) and [Cd(L)2(NO3)2] (2) (L = 2-(2-imidazolyl)-4-methyl-1,2-dihydroquinazoline-3-oxide) were synthesized by natural evaporation of Co (II)/Cd (II) nitrate with a new heterocyclic ligand. The metal complexes are characterized by elemental anal., spectroscopy, and X-ray crystallog. In the crystal structures, Co(II) complex 1 was in a six-coordinated coordination environment and constituted an infinite 1-D chain, 2-D network, Meter-shaped 3-D supramol. framework, while Cd(II) complex 2 assembled into an infinite 1-D, wave-like 2-D, and dragonfly-shaped 3-D skeleton. Specifically, nitrate ions were present as a dissociated group in complex 1, whereas complex 2 was involved in the coordination. Moreover, Cd(II) complex exhibited different fluorescence behaviors in diverse solvents. Remarkably, all the compounds showed perceptible antibacterial activity against Gram-pos. and Gram-neg. bacteria. Furthermore, the electrostatic potential (ESP) calculations were utilized to analyze electrophilic and nucleophilic attack sites on the mol., which verified the existence of hydrogen bonds in the optimized crystal structure. In addition, the structural features of metal complexes have been remarkably rationalized, and the overall trends obtained in the exptl. values have been resoundingly remake by TD/DFT calculations The detailed Hirshfeld surface anal. and fingerprint plots yielded a comparative picture of the mode of non-covalent interactions.
10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., Quality Control of 10111-08-7
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem