Imidazole based anticancer drug find applications in cancer chemotherapy. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Application of C4H4N2O.
Wu, Zhihao;Yang, Huan;Pan, Shuang;Liu, Hui;Hu, Xiaoli research published 《 Fluorescence-Scattering Dual-Signal Response of Carbon Dots@ZIF-90 for Phosphate Ratiometric Detection》, the research content is summarized as follows. Ratiometric fluorescence has drawn extensive attention owing to its self-calibration property. However, it is difficult to obtain appropriate fluorescent materials that can be excited under one excitation and possess well-resolved signals simultaneously. In this work, with the optical properties of the fluorescence of carbon dots (CDs) and the second-order scattering (SOS) of ZIF-90 (zeolitic imidazole frameworks-90) nanoparticles, the synthesized CDs@ZIF-90 can be applied to phosphate (PO43-) ratiometric detection. The fluorescence of CDs is greatly suppressed through encapsulating CDs into ZIF-90. Nevertheless, the SOS is quite obvious due to the high scattering intensity of large size ZIF-90. The competitive coordination between PO43- and the metal node of ZIF-90 decomposes CDs@ZIF-90, leading to the restoration of fluorescence and the diminution of SOS. On the basis of the PO43--induced ZIF-90 decomposition and CD release, a novel method for PO43- ratiometric detection is developed through the dual-signal response of the fluorescence scattering. Under the optimal condition, the method shows a linear range from 1.0 to 50.0μmol L-1 with a detection limit of 0.23μmol L-1. Furthermore, the probes are employed to assess PO43- in practical aqueous samples successfully. Compared with the traditional approach, which only records fluorescence signals, the method reported here provides a new strategy to design ratiometric sensors by fluorescence and scattering.
10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., Application of C4H4N2O
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem