Imidazole based anticancer drug find applications in cancer chemotherapy. 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). SDS of cas: 1739-84-0.
Wu, Shi;Huang, Jie;Wang, Yingting;Tao, Huilin;Yu, Zhongliang;Zhang, Yongfan research published 《 Bisimidazolium Tungstate Ionic Liquids: Highly Efficient Catalysts for the Synthesis of Linear Organic Carbonates by the Reaction of Ethylene Carbonate with Alcohols》, the research content is summarized as follows. A series of bisimidazolium tungstate ionic liquids were synthesized and applied to catalyze the reaction of ethylene carbonate (EC) with alcs. A detailed investigation was carried out on the relationship between catalyst structures and catalytic activities. The result showed that 1-butyl-3-methyl-bisimidazolium tungstate ([Bmim]2WO4) containing double C2-H in bisimidazolium and WO42- had more effectively catalytic performance than other bisimidazolium tungstate and conventional imidazolium salt (OAc–, Cl–, Br–). Under the optimized conditions of 1:15 molar ratio of EC and ethanol, 5 mol% [Bmim]2WO4, 85 °C and 0.5 h, the yield of di-Et carbonate (DEC) was nearly 100%. The detailed DFT calculations and NMR spectroscopy indicated that the high catalytic activity of [Bmim]2WO4 was not only because the strong nucleophilic ability of WO42- could activate ethanol, but also the special structure of double C2-H in bisimidazolium could cooperatively activate EC. The reaction was catalyzed by synergistic effect in double C2-H and WO42- of [Bmim]2WO4. In addition, [Bmim]2WO4 could be used seven times without significant loss of catalytic activity.
SDS of cas: 1739-84-0, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., 1739-84-0.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem