Imidazole based anticancer drug find applications in cancer chemotherapy. 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Computed Properties of 1739-84-0.
Vieira, Michele O.;Monteiro, Wesley F.;Ferreira, Thuany M.;Domingos, Josiel B.;Dupont, Jairton;dos Santos, Francisco P.;Scholten, Jackson D. research published 《 Surface active SNS-based dicationic ionic liquids containing amphiphilic anions: Experimental and theoretical studies of their structures and organization in solution》, the research content is summarized as follows. Surface active ionic liquids (SAILs) have been reported as new media that collectively offer the advantages of the aqueous and oily phases. In particular, dicationic ionic liquids (DILs) have attracted much interests because their tunable physicochem. properties allow them to act as sustainable active catalysts in chem. reactions (CO2 conversion, esterification) and also as extraction media to remove drugs/pollutants from aqueous systems. In order to better understand this class of ILs, this work describes new strategies for the synthesis of SNS-based dicationic ILs containing amphiphilic anions ([C12SO4]–, [C12ESO4]–, [C12BSO3]–and [C12SAR]–) and the evaluation of their structural organization and aggregation level in solution The results obtained by exptl. techniques (FTIR, TGA, DSC, POM, ESI-MS, DLS and NMR) combined with those achieved by theor. DFT calculations revealed that the anion has an important function to modulate the properties of the SNS-based ILs in solution, while the presence of a Me group at the C2 position of the imidazolium ring seems to be not sufficient to change such physicochem. properties. The ILs containing the anion [CC12BSO3]– showed a superior ionic organization in solution due to the cationic aggregates observed in the ESI(+) mode and the large size of aggregates observed by DLS. This behavior may be assigned to a close proximity of the cationic imidazolium ring and the aromatic ring in the anion (π-π interaction), and by NMR anal. (ROESY and DOSY) it was possible to confirm interactions between cation and anion. Therefore, the theor. and exptl. results obtained for the SNS-based dicationic ILs containing amphiphilic anions indicate that these ILs can be applied as media in both pure and/or solution systems for many sustainable applications.
Computed Properties of 1739-84-0, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., 1739-84-0.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem