Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Synthetic Route of 1739-84-0.
Valipour, Mehdi;Naderi, Nima;Heidarli, Elmira;Shaki, Fatemeh;Motafeghi, Farzaneh;Talebpour Amiri, Fereshteh;Emami, Saeed;Irannejad, Hamid research published 《 Design, synthesis and biological evaluation of naphthalene-derived (arylalkyl)azoles containing heterocyclic linkers as new anticonvulsants: A comprehensive in silico, in vitro, and in vivo study》, the research content is summarized as follows. In continuation of our research to find strong and safe anticonvulsant agents, a number of (arylalkyl)azoles (AAAs) containing naphthylthiazole and naphthyloxazole scaffolds were designed and synthesized. The in vivo anticonvulsant evaluations in BALB/c mice revealed that some of them had significant anticonvulsant activity in both maximal electroshock (MES) and pentylenetetrazole (PTZ) models of epilepsy. The best profile of activity was observed with compounds containing imidazole and triazole rings (C1, C6, G1, and G6). In particular, imidazolylmethyl-thiazole C1 with median ED (ED50)= 7.9 mg/kg in the MES test, ED50= 27.9 mg/kg in PTZ test, and without any sign of neurotoxicity (in the rotarod test, 100 mg/kg) was the most promising compound The patch-clamp recording was performed to study the mechanism of action of the representative compound C1 on hippocampal dentate gyrus (DG) cells. The results did not confirm any modulatory effect of C1 on the voltage-gated ion channels (VGICs) or GABAA agonism, but suggested a significant reduction of excitatory postsynaptic currents (EPSCs) frequency on hippocampal DG neurons. Sub-acute toxicity studies revealed that administration of the most active compounds (C1, C6, G1, and G6) at 100 mg/kg bw/day for two weeks did not result in any mortality or significant toxicity as evaluated by assessment of biochem. markers such as lipid peroxidation, intracellular glutathione, total antioxidant capacity, histopathol. changes, and mitochondrial functions. Other pharmacol. aspects of compounds including mechanistic and ADME properties were investigated computationally and/or exptl. Mol. docking on the NMDA and AMPA targets suggested that the introduction of the heterocyclic ring in the middle of AAAs significantly affects the affinity of the compounds The obtained results totally demonstrated that the prototype compound C1 can be considered as a new lead for the development of anticonvulsant agents.
1739-84-0, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., Synthetic Route of 1739-84-0
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem