Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Application In Synthesis of 10111-08-7.
Salomon-Santiago, Carmen;Perdomo, Gaston;Flores-Segura, Henoc;Notario, Rafael;Orozco-Guareno, E. research published 《 Experimental and theoretical thermochemical studies of imidazole, imidazole-2-carboxaldehyde and 2-aminobenzimidazole》, the research content is summarized as follows. Here were determined the molar standard enthalpies of formation, ΔfH°m (s), at T = 298.15 K of imidazole, imidazole-2-carboxaldehyde and 2-aminobenzimidazole from their resp. molar standard energies of combustion, obtained by static combustion calorimetry. Enthalpies of sublimation, ΔgsH°m, at T = 298.15 K were obtained by thermogravimetry measurements. Using data for ΔfH°m (s) and ΔgsH°m , the gas phase enthalpies of the two imidazole-derived compounds were calculated The enthalpy increases due to certain functional groups attached to the imidazole (IM) mol., and were analyzed that change in the enthalpies using the exptl. gas phase enthalpy of formation data. By using theor. methods, namely G3 and G4, the enthalpies of formation of the compounds under study were obtained and were compared with the exptl. ones. In addition, the purity, the melting temperature, the enthalpy of fusion and the heat capacity of the compounds were determined by differential scanning calorimetry.
Application In Synthesis of 10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem