Synthetic Route of 57531-37-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 57531-37-0 as follows.
Example 4246To a stirred solution of compound 45 (0.7 mmol) in dry DMF is added K2CO3 (1.4 mmol) and NaI (0.066 mmol)and stirred for 30 min at rt. Then compound 2-chloro-4nitro-imidazol (0.84 mmol) is added at rt and stirred for over night at 80 0C and the reaction is monitored by TLC. The reaction mixture is diluted with water and extracted with DCM (3 x 25 mL) and washed with water, brine and dried (over with Na2SO4) and concentrated under vacuum. The crude compound is purified over neutral alumina using 30percent EtOAc/pet-ether as eluent to give 46. MS: M+ 396.3
According to the analysis of related databases, 57531-37-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GmbH; US DEPARTMENT OF HEALTH & HUMAN SERVICES; WO2007/75872; (2007); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem