Imidazole based anticancer drug find applications in cancer chemotherapy. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Electric Literature of 3034-50-2.
Nguyen, Huong T. D.;Nguyen, The T.;Nguyen, Phuong T. K.;Tran, Phuong Hoang research published 《 A highly active copper-based metal-organic framework catalyst for a Friedel-Crafts alkylation in the synthesis of bis(indolyl)methanes under ultrasound irradiation》, the research content is summarized as follows. A robust copper-based metal-organic framework (MOF) catalyst, termed as MOF-891, was successfully applied to the synthesis of the family of bioactive compounds, bis(indolyl)methanes I (R1 = H, 5-NO2, 5-Me, 5-Br; R2 = 3-bromophenyl, 4-methoxyphenyl, 1H-imidazol-4-yl, etc.), through a Friedel-Crafts alkylation under ultrasound irradiation The remarkable catalytic activity of MOF-891 was proven by the successful synthesis of bis(indolyl)methanes I in high yield (up to 96%) and purity. In MOF-891, there exist two types of copper clusters, one discrete and one infinite rod, both are formed through water mols. triggering hydrogen bonds demonstrated the participation as catalytic active site for the Friedel-Crafts alkylation reaction. The well-defined construction of hydrogen bonds in MOF-891 along with Lewis copper sites attributed a stable catalysis activity and exhibited the heterogeneous nature with no significant loss of catalytic performance after six cycles.
3034-50-2, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, Electric Literature of 3034-50-2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem