Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Name: 1H-Imidazole-2-carbaldehyde.
Mukherjee, Arpan;Koley, Tuhin Subhra;Chakraborty, Ayan;Purkait, Kallol;Mukherjee, Arindam research published 《 Synthesis, Structure and Cytotoxicity of N,N and N,O-Coordinated RuII Complexes of 3-Aminobenzoate Schiff Bases against Triple-negative Breast Cancer》, the research content is summarized as follows. Half-sandwich RuII complexes, [(YZ)RuII(η6-arene)(X)]+, (YZ = chelating Schiff base bidentate ligand, X = halide), with N,N and N,O coordination show significant antiproliferative activity against the metastatic triple-neg. breast carcinoma (MDA-MB-231). 3-Aminobenzoic acid or its Me ester is used in all the ligands as an amine component, while varying the aldehyde for N,N and N,O coordination. In the N,N coordinated complex the coordinated halide(X) is varied for enhancing stability in solution (X = Cl, I). Rapid aquation and halide exchange of the pyridine analogs in solution are a major bane towards their antiproliferative activity. Presence of free carboxy group make complexes hydrophilic and reduces toxicity. The imidazolyl 3-aminobenzoate based N,N coordinated complexes display better solution stability and efficient antiproliferative activity (IC50 ca. 2.3-2.5μM) compared to the pyridine based analogs (IC50>100μM) or the N,O coordinated complexes (IC50 ca. 7-10μM). The iodido coordinated complex is resistant towards aquation and halide exchange. The N,O coordinated complexes underwent instantaneous aquation at pH 7.4 generating monoaquated complexes stable for at least 6 h. Binding to 9-ethylguanine (9-EtG) was examined showing propensity to interact with DNA bases. The complexes may kill via apoptosis as displayed from the study of the iodide complex. The change in coordination mode and the aldehyde affected the solution stability, antiproliferative activity and mechanistic pathways. The N,N coordinated complexes exhibit arrest in the G2/M phase while the N,O coordinated showed arrest in the G0/G1 phase.
Name: 1H-Imidazole-2-carbaldehyde, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem