On March 31, 2011, Buckman, Brad; Nicholas, John B.; Beigelman, Leonid; Serebryany, Vladimir; Stoycheva, Antitsa Dimitrova; Thrailkill, Timothy; Seiwert, Scott D. published a patent.Recommanded Product: 4-Bromo-1H-benzo[d]imidazol-2(3H)-one The title of the patent was Preparation of macrocyclic peptides, especially proline-containing peptides, as inhibitors of hepatitis C virus replication for treating hepatitis C infection and liver fibrosis. And the patent contained the following:
The invention is related to the preparation of title compounds, e.g., I [R1 = COOBu-t, (un)substituted (hetero)aryl, etc.; R2 = (un)substituted 1-alkylbenzimidazol-2-yloxy, 2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinazolin-4-yloxy, 5-aryl-2H-tetrazol-2-yl, etc.; R3 = OH, NHSO2R3a, NHSO2OR3a; NHSO2NR3bR3c; R3a = (un)substituted alkyl, aryl, cycloalkyl, etc.; R3b, R3c = independently H, (un)substituted alkyl, C6 or C10 aryl, etc.; or NR3bR3c = (un)substituted 3-6 membered heterocyclyl bonded to the parent structure through a N ; with provisos], pharmaceutical acceptable salts and prodrugs and their compositions containing them as inhibitors of hepatitis C virus replication. The invention is also related to methods of treating a hepatitis C virus infection and methods of treating liver fibrosis. Thus, II·HCl was prepared by a multi-step synthesis and displayed an EC50 between 10 and 100 nM and an IC50 < 10 nM in an NS3-NS4 inhibitory activity assay. The experimental process involved the reaction of 4-Bromo-1H-benzo[d]imidazol-2(3H)-one(cas: 40644-16-4).Recommanded Product: 4-Bromo-1H-benzo[d]imidazol-2(3H)-one
The Article related to cyclic peptide preparation hepatitis c virus replication inhibitor, ns3 ns4a protease inhibitor hcv infection fibrosis macrocycle preparation, proline peptide peptidomimetic preparation inhibitor hcv replication and other aspects.Recommanded Product: 4-Bromo-1H-benzo[d]imidazol-2(3H)-one
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem