On March 13, 1979, Clark, Robert L.; Pessolano, Arsenio A.; Shen, Tsung-Ying published a patent.Quality Control of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one The title of the patent was Imidazopyridin-2-ones and pharmaceutical compositions and methods of treatment. And the patent contained the following:
Imidazopyridines I [R = H, C2-6 alkenyl, C1-7 alkyl (substituted with C3-6 cycloalkyl, C1-5 alkoxy, or OH), C4-7 cycloalkyl; R1, R2, R4 = H, 5- or 6-F, 5- or 6-Cl, 5- or 6-C1-5 alkoxycarbonylamino; R1R2 = OCR5R6O (R5, R6 = H, alkyl)] were prepared by several methods. Also prepared were 3-heterocyclyl analogs of I and 2-thiono analogs of I. I and their analogs were analgesics, antipyretics, and antiinflammatory agents (no data). Thus, refluxing 2-chloro-3-nitropyridine with 3,4-(OCH2O)C6H3NH2 in NaOAc-AcOH 5 h gave nitropyridine II (R7 = NO2) which was hydrogenated over Pd/C in MeOH and the diamine II (R7 = NH2) cyclized with COCl2 overnight at room temperature to give I (R = R4 = H, R1R2 = 3,4-OCH2O), which was converted into a variety of I (R = alkyl, alkenyl, acyl, R1R2 = OCH2O, R4 = H). The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Quality Control of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
The Article related to analgesic imidazopyridinone preparation, antipyretic imidazopyridinone preparation, antiinflammatory imidazopyridinone preparation, imidazopyridinone pharmaceutical preparation, aminoanilinopyridine cyclization phosgene and other aspects.Quality Control of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem