Application of 870837-18-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 870837-18-6, name is 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Step B: To a solution of 1 10 mg (0.497 mmol) of 1 -(1 -(4-fluorophenyl)ethyl)piperidin-2- one A6a in THF (2 ml) was added 1 .24 mL of 2M LDA (in THF/Heptane, Acros) at -78 C. The reaction was stirred for 30 min at -78 C, then stirred for 30 min at -20 C, and was re-cooled to -78 C. Added 3-methoxy-4-(4-methyl-1 H-imidazol-1 – yl)benzaldehyde as solid and stirred for 30 min. The mixture was quenched with saturated aqueous NaHCtheta3, extracted with EtOAc (2 times), and washed with brine (2X). The organic phase was dried (MgSO4) and concentrated. The product was purified by a gradient reverse-phase HPLC (CH3CN-H2O with 0.1% formic acid) to furnish 1 10 mg of the product A6. (ES-LCMS, M+1) 438.2. Retention time: 2.94 min.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SCHERING CORPORATION; WO2009/108766; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem