On February 1, 2022, Nikitin, E. A.; Shpakovsky, D. B.; Tyurin, V. Yu; Kazak, A. A.; Gracheva, Yu A.; Vasilichin, V. A.; Pavlyukov, M. S.; Mironova, E. M.; Gontcharenko, V. E.; Lyssenko, K. A.; Antonets, A. A.; Dubova, L. G.; Shevtsov, P. N.; Shevtsova, E. F.; Shamraeva, M. A.; Shtil, A. A.; Milaeva, E. R. published an article.Recommanded Product: 5036-48-6 The title of the article was Novel organotin complexes with phenol and imidazole moieties for optimized antitumor properties. And the article contained the following:
A series of novel imidazole-containing ligands and their organotin complexes were synthesized and characterized by NMR, IR, MALDI and elemental anal. Redox behavior was studied by cyclic voltammetry (CV). Antioxidant properties were estimated in model reactions of single-electron reduction (CUPRAC-test), scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and O-.2 radical anion, enzymic oxidation of linoleic acid by lipoxygenase and Fe3+-induced lipid peroxidation of rat liver homogenates. It was found that ligands and complexes both possess radical scavenging activity of prolonged action type. Compounds exhibited notable antioxidant activity in lipid peroxidation Cytotoxicity was estimated in standard MTT-test on multiple cell lines. Compounds demonstrated high toxicity on colon carcinoma and breast cancer cells and based on obtained data, lead compound was proposed. Addnl. assays were carried out for the lead compound, including regular MTT-test on cancer cells possessing various resistant mechanisms and modified MTT-test on tumor tissue samples, obtained from patients as well as apoptosis and cell cycle studies. All organotin complexes were also studied for their influence on tubulin polymerization It was demonstrated that obtained compounds demonstrate unorthodox activity, promoting microtubules assembly rate instead of inhibiting it. Significant influence of compound 5 on G2/M phase of cell cycle is in accordance with influence on tubulin polymerization and lets us to mark synthesized compounds as mitotic poisons. The results open up the scopes for the search of novel antitumor agents for treatment of advanced forms of cancer. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Recommanded Product: 5036-48-6
The Article related to organotin complex phenol imidazole human antitumor breast colon ovary, electrochem preparation organotin complex phenol imidazole, cytotoxicity antioxidant organotin complex phenol imidazole preparation, crystal structure mol optimized organotin complex phenol imidazole moiety and other aspects.Recommanded Product: 5036-48-6
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem