41716-18-1, name is 1-Methyl-1H-imidazole-4-carboxylic acid, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C5H6N2O2
Step 6. Synthesis of A/-((1 f?*,3S*)-3-((2-(5-cyano-7-fluoro-1 -tosyl-1 /-/-indol-3-yl)-5- fluoro rimidin-4-yl)amino)cyclohexyl)-1 -methyl-1 /- -imidazole-4-carboxamide. HBTU (522 mg, 1 .38 mmol) was added to a solution of 1 -methyl-1 -/-imidazole-4- carboxylic acid (50.7 mg, 0.40 mmol) in THF (2.5 ml.) at room temperature for 5 minutes under inert atmosphere. Then, a solution of 3-(4-(((1 S*,3 ?*)-3-amino- cyclohexyl)amino)-5-fluoropyrimidin-2-yl)-7-fluoro-1 -tosyl-1 – -indole-5-carbonitrile (200 mg, 0.38 mmol) and A ,A/-diisopropylethylamine (0.24 mL, 1 .38 mmol) in DMSO (0.5 mL) was added and the stirring continued at room temperature for 12 hours. The reaction mixture was diluted with water and extracted with DCM. The organic layers were concentrated under reduced pressure to give a crude that was purified by column chromatography eluting with heptane-EtOAc to yield N- ((1 f?*,3S*)-3-((2-(5-cyano-7-fluoro-1 -tosyl-1 H-indol-3-yl)-5-fluoropyrimidin-4- yl)amino)cyclohexyl)-1 -methyl-1 H-imidazole-4-carboxamide (150 mg, 0.23 mmol). LC-MS ES+ m/z = 631 .2; Rt: 1 .09 min, method E.
The synthetic route of 41716-18-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN SCIENCES IRELAND UC; JONCKERS, Tim, Hugo, Maria; RABOISSON, Pierre, Jean-Marie, Bernard; GUILLEMONT, Jerome, Emile, Georges; MC GOWAN, David, Craig; EMBRECHTS, Werner, Constant, Johan; COOYMANS, Ludwig, Paul; MICHAUT, Antoine, Benjamin; (162 pag.)WO2016/20526; (2016); A1;,
Imidazole – Wikipedia,
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