《Synthetic enzyme-based nanoparticles act as smart catalyst for glucose responsive release of insulin》 was written by Jana, Baishali A.; Shinde, Ujwala; Wadhwani, Ashish. Product Details of 7720-39-0 And the article was included in Journal of Biotechnology in 2020. The article conveys some information:
This study aimed to assess faster responsiveness of insulin release from this enzyme based nanoparticles which is self-regulated insulin delivery system constructed by loading with insulin, enzyme glucose oxidase into hyaluronic acid and 2-nitroimidazole forming enzyme-based nanoparticles which works in accordance to the blood glucose level. Enzyme-based nanoparticles were prepared by ionic gelation method. Insulin content in nanoparticles kept for stability study was estimated by human insulin enzyme based immunosorbent assay. In in-vitro studies; different concentrations of glucose were taken and the release study of insulin was recorded. This enzyme-based nanoparticles were having average diameter of around 193 nm and stability studies showed that nanoparticles were stable up to 30 days at 4°C. In-vitro studies showed the release of insulin from nanoparticle conjugates which was effectively correlated with the external glucose concentration created where different concentrations of glucose taken thus facilitating the stabilization of blood glucose levels in the hyperglycemia state which was achieved within 10 min. wherein drug release rate remarkably increased in hyperglycemia state and no specific changes or small amount of release was observed in normoglycemia state (100 mg/dL). Preliminary study of this enzyme-based nanoparticles formulation showed excellent rapid responsiveness towards hyperglycemia which might act as potential biomimetic system in triggering release of insulin in sustained manner. The experimental process involved the reaction of 1H-Imidazol-2-amine(cas: 7720-39-0Product Details of 7720-39-0)
1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Product Details of 7720-39-0
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem