Related Products of 7720-39-0In 2021 ,《A scaffold hopping strategy to generate new aryl-2-amino pyrimidine MRSA biofilm inhibitors》 was published in RSC Medicinal Chemistry. The article was written by Weig, Alexander W.; Barlock, Samantha L.; O’Connor, Patrick M.; Marciano, Orry M.; Smith, Richard; Ernst, Robert K.; Melander, Roberta J.; Melander, Christian. The article contains the following contents:
Infections that stem from bacterial biofilms are difficult to eradicate. Within a biofilm state, bacteria are upwards of 1000-fold more resistant to conventional antibiotics, necessitating the development of alternative approaches to treat biofilm-based infections. One such approach is the development of small mol. adjuvants that can inhibit/disrupt bacterial biofilms. When such mols. are paired with conventional antibiotics, these dual treatments present a combination approach to eradicate biofilm-based infections. Previously, we have demonstrated that small mols. containing either a 2-amino pyrimidine (2-AP) or a 2-aminoimidazole (2-AI) heterocycle are potent anti-biofilm agents. Herein, we now report a scaffold hopping strategy to generate new aryl 2-AP analogs that inhibit biofilm formation by methicillin-resistant Staphylococcus aureus (MRSA). These mols. also suppress colistin resistance in colistin resistant Klebsiella pneumoniae, lowering the min. inhibitory concentration (MIC) by 32-fold. The results came from multiple reactions, including the reaction of 1H-Imidazol-2-amine(cas: 7720-39-0Related Products of 7720-39-0)
1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Related Products of 7720-39-0
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem