In 1977,Journal of Medicinal Chemistry included an article by Kohn, Harold; Kohn, Barbara A.; Steenberg, Marie L.; Buckley, Joseph P.. Application of 60546-77-2. The article was titled 《Syntheses and pharmacological activity of substituted imidazolidinethiones and thioimidazolines》. The information in the text is summarized as follows:
Five title compounds, prepared by S-alkylation or N-acetylation of the appropriate imidazolidinethiones, all decreased respiration and body temperature and produced ptosis in rats in gross observation studies. Thioimidazolines N-carbomethoxy- (I) [60546-77-2] and N-acetyl-2-methylthioimidazoline (II) [60546-75-0] were the most active central nervous system depressants and had the highest safety index. The isomeric imidazolidinethiones N-carbomethoxy- (III) [60546-78-3] and N-acetyl-N’-methylimidazolidinethione (IV) [60546-76-1] were much less effective and were much more toxic. NMR and ir spectra of the compounds are presented and discussed. The results came from multiple reactions, including the reaction of Methyl 2-(methylthio)-4,5-dihydro-1H-imidazole-1-carboxylate(cas: 60546-77-2Application of 60546-77-2)
Methyl 2-(methylthio)-4,5-dihydro-1H-imidazole-1-carboxylate(cas: 60546-77-2) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.Application of 60546-77-2 Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem