《Metal-Organic Frameworks Conjugated Lipase with Enhanced Bio-catalytic Activity and Stability》 was written by Zou, Bin; Zhang, Liming; Xia, Jiaojiao; Wang, Pengyun; Yan, Yan; Wang, Xinyi; Adesanya, Idowu Onyinye. Related Products of 530-62-1 And the article was included in Applied Biochemistry and Biotechnology in 2020. The article conveys some information:
Covalent immobilization of lipase onto a solid carrier is an effective way to enhance stability. Immobilization inhibits the activity of lipase due to decreased flexibility of enzyme structure via the covalent bond. In this study, monomer of the metal-organic frameworks (MOFs) material ZIF-8 (2-Me imidazole-4-carboxylic acid) was innovatively used as a chem. modifier of Candida nrugosa lipase (CRL). The CD spectra results show that the CRL mol. was altered by chem. modification and thus its catalytic activity was 1.3 times higher than that of the free CRL. The modified CRL mol. was further immobilized in the “”skeleton”” of ZIF-8 through the monomer while in situ forming the cell skeleton of the MOFs, which prevent the active center from being destroyed. The results show that conjugation of chem. modification and immobilized enzymes ensure that there was no obvious reduction in the activity of CRL after immobilization and the stability of CRL was improved. Especially, the organic solvent stability of the modified immobilization CRL in isopropanol was significantly improved and retained more than 148% of its activity.Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Related Products of 530-62-1) was used in this study.
Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a coupling agent in the synthesis of dipolar polyamides for nonlinear optical applications and polypeptides. It also used to make β-keto sulfones and sulfoxides, lead sequestering agents, and β-enamino acid derivatives.Related Products of 530-62-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem