《Thiolate Bridged Gold(I)-NHC Catalysts: New Approach for Catalyst Design and its Application to Trapping Catalytic Intermediates》 was published in Chemistry – A European Journal in 2019. These research results belong to Visbal, Renso; Herrera, Raquel P.; Gimeno, M. Concepcion. Category: imidazoles-derivatives The article mentions the following:
New dinuclear N-heterocyclic carbene gold complexes [[(NHC)Au]2(μ-SC6F5)][OTf] (5-8; NHC = IPr, SIPr, IMes, SIMes) with bridging thiolate ligands have been designed as catalytic precursors with desired properties such as stability, recyclability and that do not require additives. The dinuclear compounds 5-8 could slowly release the active catalytic species [Au(NHC)]+ and the precursor [Au(SC6F5)(NHC)] in solution, which means that both species would remain stable throughout the catalytic cycle and the pre-catalyst could easily be recovered. The properties exhibited by the complexes have been taken advantage of to gain new insights on the gold-catalyzed hydroalkoxylation of alkynes, with the aim of clarifying all the steps of the catalytic cycle, together with the characterization of intermediates and final products. Isolation and characterization of the pure final spiroketals and the thermodn. intermediate have been achieved for the first time. Moreover, the kinetic intermediate has also been detected for the first time. In the experimental materials used by the author, we found Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2Category: imidazoles-derivatives)
Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. Category: imidazoles-derivatives In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem