《Micellar nanocarriers from dendritic macromolecules containing fluorescent coumarin moieties》 was written by Concellon, Alberto; Anselmo, Maria San; Hernandez-Ainsa, Silvia; Romero, Pilar; Marcos, Mercedes; Serrano, Jose Luis. HPLC of Formula: 530-62-1 And the article was included in Polymers (Basel, Switzerland) in 2020. The article conveys some information:
The design of efficient drug-delivery vehicles remains a big challenge in materials science. Herein, we describe a novel class of amphiphilic hybrid dendrimers that consist of a poly(amidoamine) (PAMAM) dendritic core functionalized with bisMPA dendrons bearing cholesterol and coumarin moieties. Their self-assembly behavior both in bulk and in water was investigated. All dendrimers exhibited smectic A or hexagonal columnar liquid crystal organizations, depending on the generation of the dendrimer. In water, these dendrimers self-assembled to form stable spherical micelles that could encapsulate Nile Red, a hydrophobic model compound The cell viability in vitro of the micelles was studied in HeLa cell line, and proved to be non-toxic up to 72 h of incubation. Therefore, these spherical micelles allow the encapsulation of hydrophobic mols., and at the same time provided fluorescent traceability due to the presence of coumarin units in their chem. structure, demonstrating the potential of these dendrimers as nanocarriers for drug-delivery applications. In the experiment, the researchers used many compounds, for example, Di(1H-imidazol-1-yl)methanone(cas: 530-62-1HPLC of Formula: 530-62-1)
Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a coupling agent in the synthesis of dipolar polyamides for nonlinear optical applications and polypeptides. It also used to make β-keto sulfones and sulfoxides, lead sequestering agents, and β-enamino acid derivatives.HPLC of Formula: 530-62-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem