Chen, Nan; Yang, Hao; Li, Qing; Song, Lijun; Gopinath, Subash C. B.; Wu, Di published an article in 2021. The article was titled 《An interdigitated aptasensor to detect interleukin-6 for diagnosing rheumatoid arthritis in serum》, and you may find the article in Biotechnology and Applied Biochemistry.HPLC of Formula: 530-62-1 The information in the text is summarized as follows:
Rheumatoid arthritis (RA) is an autoimmune disorder causing chronic inflammation in the small joints of the articular bone and destruction of articular cartilage. RA causes stiffness, pain, joint destruction, substantial comorbidity, and functional disability. Early-stage diagnosis of RA can help in the treatment of the disease and expand the patient life span. Interleukins are a group of inflammatory cytokines; in particular, an abundance of interleukin-6 (IL-6) was found in the synovial fluid and serum. In RA patients, the levels of IL-6 have been found to be correlated with the disease, and this work focused on detecting IL-6 by its aptamer with the help of a biotin-streptavidin strategy on an interdigitated electrode. A sensitivity of 1 fM (0.021 pg/mL) and a limit of detection of 10 fM (0.21 pg/mL) were found by a linear regression [y = 0.6413x – 0.6249; R2 = 0.952] of the linear range from 1 fM to 100 pM. This method enhanced the immobilization of higher aptamer mols. for recognizing RA in serum-containing samples and is applicable to other diseases. In the experimental materials used by the author, we found Di(1H-imidazol-1-yl)methanone(cas: 530-62-1HPLC of Formula: 530-62-1)
Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.HPLC of Formula: 530-62-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem