In 2022,St-Jean, Frederic; Angelaud, Remy; Bachmann, Stephan; Carrera, Diane E.; Remarchuk, Travis; Piechowicz, Katarzyna A.; Niedermann, Katrin; Iding, Hans; Meier, Roland; Hou, Haiyun; Sirois, Lauren E.; Xu, Jie; Olbrich, Martin; Rege, Pankaj; Guillemot-Plass, Maud; Gosselin, Francis published an article in Journal of Organic Chemistry. The title of the article was 《Stereoselective Synthesis of the IDO Inhibitor Navoximod》.COA of Formula: C3H3BrN2 The author mentioned the following in the article:
A highly efficient asym. synthesis of the IDO inhibitor navoximod, featuring the stereoselective installation of two relative and two absolute stereocenters from an advanced racemic intermediate, was described. The stereocenters were set via a crystallization-induced dynamic resolution along with two selective ketone reductions: one via a biocatalytic ketoreductase transformation and one via substrate-controlled hydride delivery from LiAlH(Ot-Bu)3. Following this strategy, navoximod were synthesized in 10 steps from 2-fluorobenzaldehyde and isolated in 23% overall yield with 99.8% ee and high purity. The experimental part of the paper was very detailed, including the reaction process of 2-Bromo-1H-imidazole(cas: 16681-56-4COA of Formula: C3H3BrN2)
2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. COA of Formula: C3H3BrN2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem