Related Products of 7720-39-0In 2017 ,《Enhanced nonenzymatic RNA copying with 2-aminoimidazole activated nucleotides》 was published in Journal of the American Chemical Society. The article was written by Li, Li; Prywes, Noam; Tam, Chun Pong; O’Flaherty, Derek K.; Lelyveld, Victor S.; Izgu, Enver Cagri; Pal, Ayan; Szostak, Jack W.. The article contains the following contents:
Achieving efficient nonenzymic replication of RNA is an important step toward the synthesis of self-replicating protocells that may mimic early forms of life. Despite recent progress, the nonenzymic copying of templates containing mixed sequences remains slow and inefficient. Here we demonstrate that activating nucleotides with 2-aminoimidazole results in superior reaction kinetics and improved yields of primer extension reaction products. This new leaving group significantly accelerates monomer addition as well as trimer-assisted RNA primer extension, allowing efficient copying of a variety of short RNA templates with mixed sequences. In the experiment, the researchers used 1H-Imidazol-2-amine(cas: 7720-39-0Related Products of 7720-39-0)
1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Related Products of 7720-39-0
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem