《Synthesis of novel fluorophenylpyrazole-picolinamide derivatives and determination of their anticancer activity》 was written by Kankala, Shravankumar; Rama, Koteshwar Rao; Kesari, Chekrapani; Bjorkling, Fredrik; Nerella, Srinivas; Gundepaka, Prasad; Guguloth, Hanmanthu; Thota, Niranjan. Application of 141556-45-8 And the article was included in Synthetic Communications in 2020. The article conveys some information:
A series of fluorophenylpyrazole-picolinamide derivatives were synthesized in high yields using a cross-coupling reaction catalyzed by in-situ formed palladium-N-heterocyclic carbenes (Pd-NHCs). The synthesized novel derivatives were evaluated for in-vitro anticancer activity against a panel of four human tumor cell lines, HeLa (cervical), A-549 (lung), MCF-7 (breast), and IMR-32 (neuroblastoma). Four compounds showed growth inhibition (low μM) comparable with the standard drug cisplatin, provided a preliminary structure-activity relationship for the series. The present procedure was operationally simple and worked with a wide range of substrates and may thus be useful in further compound optimization. The experimental part of the paper was very detailed, including the reaction process of 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8Application of 141556-45-8)
1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.Application of 141556-45-8
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem