Beaulieu, Francis; Ouellet, Carl; Ruediger, Edward H.; Belema, Makonen; Qiu, Yuping; Yang, Xuejie; Banville, Jacques; Burke, James R.; Gregor, Kurt R.; MacMaster, John F.; Martel, Alain; McIntyre, Kim W.; Pattoli, Mark A.; Zusi, F. Christopher; Vyas, Dolatrai published the artcile< Synthesis and biological evaluation of 4-amino derivatives of benzimidazoquinoxaline, benzimidazoquinoline, and benzopyrazoloquinazoline as potent IKK inhibitors>, COA of Formula: C4H5BrN2, the main research area is amino derivative benzimidazoquinoxaline benzimidazoquinoline benzopyrazoloquinazoline preparation IKK inhibitor.
The authors have recently identified BMS-345541 (I) as a highly selective and potent inhibitor of IKK-2 (IC50 = 0.30 μM), which however was considerably less potent against IKK-1 (IC50 = 4.0 μM). In order to further explore the SAR around the imidazoquinoxaline tricyclic structure of I, the authors prepared a series of tetracyclic analogs, e.g. II (R = Me, CH2CH2NHMe.HCl, CH2CH2OH, 2-piperidinoethyl). The synthesis and biol. activities of these potent IKK inhibitors are described.
Bioorganic & Medicinal Chemistry Letters published new progress about Soluble tumor necrosis factors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, COA of Formula: C4H5BrN2.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem