In 2022,Saeedian Moghadam, Ebrahim; Al-Saadi, Abdullah Mohammed; Talebi, Meysam; Amanlou, Massoud; Amini, Mohsen; Abdel-Jalil, Raid published an article in Synthetic Communications. The title of the article was 《Design, synthesis, and bioactivity investigation of novel benzimidazole derivatives as potent urease inhibitors》.Product Details of 934-32-7 The author mentioned the following in the article:
Herein, we synthesized a series of novel benzimidazole derivatives and screened their bioactivity as potent urease inhibitors. The structure of the was elucidated using spectroscopic technics (1H-NMR, 13C-NMR, MS), elemental anal., and m.p. The urease inhibition activity was evaluated using the urease enzyme inhibition kit. All , except , showed higher urease inhibition activity (0.77 to 6.25 μM) in comparison to thiourea and hydroxyurea as standard (IC50: 22 and 100 μM resp.). and exhibited the best activity with the IC50 value of 0.77 and 1.26 μM resp. A mol. docking study showed the mode of interactions between the most active compound and enzyme active site. To investigate the cytotoxicity profile of the target compounds, an MTT assay was done on two different cell lines which showed all have IC50 values higher than 50 μM on both tested cell lines.1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Product Details of 934-32-7) was used in this study.
1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Product Details of 934-32-7
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem