Li, Minshu; Li, Xiuping; Wang, Dan; Gao, Xiaolin; Li, Shiyao; Cheng, Xiaojing; Shen, Yiming; Li, Shenghui; Jia, Qiang; Liu, Qiang published the artcile< Inhibition of exosome release augments neuroinflammation following intracerebral hemorrhage>, Application In Synthesis of 6823-69-4, the main research area is intracerebral hemorrhage neuroinflammation exosome; exosome; immunity; intracerebral hemorrhage; neuroinflammation.
Intracerebral hemorrhage (ICH) is a severe stroke subtype without effective pharmacol. treatment. Following ICH, peripheral leukocytes infiltrate into the brain and contribute to neuroinflammation and brain edema. However, the intercellular machinery controlling the initiation and propagation of leukocyte infiltration remains elusive. Exosomes are small extracellular vesicles released from donor cells and bridge intercellular communication. In this study, we investigated the effects of inhibition of exosome release on neuroinflammation and ICH injury. Using a mouse model of ICH induced by collagenase injection, we found that ICH induced an increase of exosome level in the brain. Inhibition of exosome release using GW4869 augmented neurol. deficits and brain edema after ICH. The exacerbation of ICH injury was accompanied by increased barrier disruption and brain infiltration of leukocytes. The detrimental effects of GW4869 were ablated in ICH mice receiving antibody depletion of Gr-1+ myeloid cells. Extracted exosomes from the ICH brains suppressed the production of inflammatory factors by splenocytes. Addnl., exosomes extracted from brain tissues of donor ICH mice reduced ICH injury in recipient mice. These results demonstrate that inhibition of exosome release augments neuroinflammation and ICH injury. The impact of exosomes released from the ICH brain on the immune system deserves further investigation.
FASEB Journal published new progress about Brain. 6823-69-4 belongs to class imidazoles-derivatives, and the molecular formula is C30H30Cl2N6O2, Application In Synthesis of 6823-69-4.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem