The author of 《Synthesis of novel galeterone derivatives and evaluation of their in vitro activity against prostate cancer cell lines》 were Jorda, Radek; Reznickova, Eva; Kielczewska, Urszula; Maj, Jadwiga; Morzycki, Jacek W.; Siergiejczyk, Leszek; Bazgier, Vaclav; Berka, Karel; Rarova, Lucie; Wojtkielewicz, Agnieszka. And the article was published in European Journal of Medicinal Chemistry in 2019. HPLC of Formula: 7720-39-0 The author mentioned the following in the article:
Prostate cancer is one of the main causes of male cancer-related deaths worldwide and the suppression of androgen receptor signalling is established as an effective strategy for the treatment. A series of galeterone analogs including several steroid-fused azacycles, as well as 17-(benzimidazol-1-ylimino), 16α-(benzimidazol-2-ylamino), and 16α-(benzothiazol-2-ylamino) steroid derivatives, were synthesized and tested against prostate cancer cell lines. Candidate compound I was shown to reduce AR-regulated transcription in a dose-dependent manner in nanomolar ranges and suppress expression of AR-regulated proteins Nkx3.1 and PSA in 22Rv1-ARE14 and VCaP cancer cell lines. Flexible docking study revealed similar position of I within AR binding site in comparison of galeterone even with stronger binding energy.1H-Imidazol-2-amine(cas: 7720-39-0HPLC of Formula: 7720-39-0) was used in this study.
1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.HPLC of Formula: 7720-39-0
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem