《A quantitative empirical directing group scale for selectivity in iridium-catalysed hydrogen isotope exchange reactions》 was published in Catalysis Science & Technology in 2020. These research results belong to Timofeeva, Daria S.; Lindsay, David M.; Kerr, William J.; Nelson, David J.. Synthetic Route of C21H25ClN2 The article mentions the following:
A palette of commonly used directing groups, including various pharmaceutically relevant nitrogen-containing heterocycles, are quant. ranked based on the results of intermol. hydrogen isotope exchange competition reactions using two iridium complexes: [Ir(COD)(IMes)(PPh3)][BArF24] and [IrCl(COD)(IMes)]. The directing group power scales that have been constructed from these data reveal a wide range of reactivity covering four orders of magnitude. Intramol. competition experiments have demonstrated that the obtained reactivity scale provides accurate predictions of regioselectivity within mols. with multiple competing directing groups. This work contributes to our understanding and control of regioselectivity in metal-catalyzed C-H activation reactions. The experimental part of the paper was very detailed, including the reaction process of 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8Synthetic Route of C21H25ClN2)
1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.Synthetic Route of C21H25ClN2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem