《Combined Photoredox and Carbene Catalysis for the Synthesis of Ketones from Carboxylic Acids》 was written by Bay, Anna V.; Fitzpatrick, Keegan P.; Betori, Rick C.; Scheidt, Karl A.. Application of 530-62-1 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:
As a key element in the construction of complex organic scaffolds, the formation of C-C bonds remains a challenge in the field of synthetic organic chem. Recent advancements in single-electron chem. have enabled new methods for the formation of various C-C bonds. Disclosed herein is the development of a novel single-electron reduction of acyl azoliums for the formation of ketones from carboxylic acids. Facile construction of the acyl azolium in situ followed by a radical-radical coupling was made possible merging N-heterocyclic carbene (NHC) and photoredox catalysis. The utility of this protocol in synthesis was showcased in the late-stage functionalization of a variety of pharmaceutical compounds Preliminary studies using chiral NHCs demonstrate that enantioselectivity can be achieved, showcasing the advantages of this protocol over alternative methodologies. The experimental process involved the reaction of Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Application of 530-62-1)
Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a coupling agent in the synthesis of dipolar polyamides for nonlinear optical applications and polypeptides. It also used to make β-keto sulfones and sulfoxides, lead sequestering agents, and β-enamino acid derivatives.Application of 530-62-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem