In 2017,Draughn, G. Logan; Allen, C. Leigh; Routh, Patricia A.; Stone, Maria R.; Kirker, Kelly R.; Boegli, Laura; Schuchman, Ryan M.; Linder, Keith E.; Baynes, Ronald E.; James, Garth; Melander, Christian; Pollard, Angela; Cavanagh, John published 《Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections》.Drug Design, Development and Therapy published the findings.Quality Control of 1H-Imidazol-2-amine The information in the text is summarized as follows:
2-Aminoimidazole (2-AI)-based compounds have been shown to efficiently disrupt biofilm formation, disperse existing biofilms, and resensitize numerous multidrug-resistant bacteria to antibiotics. Using Pseudomonas aeruginosa and Staphylococcus aureus, we provide initial pharmacol. studies regarding the application of a 2-AI as a topical adjuvant for persistent dermal infections. In vitro assays indicated that the 2-AI H10 is nonbactericidal, resensitizes bacteria to antibiotics, does not harm the integument, and promotes wound healing. Furthermore, in vivo application of H10 on swine skin caused no gross abnormalities or immune reactions. Taken together, these results indicate that H10 represents a promising lead dermal adjuvant compound The experimental process involved the reaction of 1H-Imidazol-2-amine(cas: 7720-39-0Quality Control of 1H-Imidazol-2-amine)
1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Quality Control of 1H-Imidazol-2-amine
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem