COA of Formula: C3H5N3In 2017 ,《2-Aminoimidazoles: synthesis by ring transformation reactions》 appeared in Studies in Natural Products Chemistry. The author of the article were Babaev, Eugene V.. The article conveys some information:
A review. Marine sponges belonging to the Calcarea family have been proven to be a source of biol. active alkaloids and their metabolites. Two Calcarea genera, Leucetta and Clathrina, have been found to contain more than 60 examples of imidazole alkaloids during the last 30 years. Since the first discovery of 2-aminoimidazole (2-Al) alkaloids in marine sponges by Kashman’s group in 1987. A number of preclathridine and isonaamine alkaloids, representing a family of 1,4-substituted 2-aminoimidazoles bearing one or two substituted benzyl moieties, have been isolated and synthesized in the last decades (see Scheme 2.1) [2]. Of course, the number of 2-AI is not exhausted by these examples; the series is much broader [3]. Many 2-AI alkaloids have been reported to have cytotoxic, antimicrobial, or antifungal properties [4,5],and this topic was recently well reviewed. In addition to this study using 1H-Imidazol-2-amine, there are many other studies that have used 1H-Imidazol-2-amine(cas: 7720-39-0COA of Formula: C3H5N3) was used in this study.
1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.COA of Formula: C3H5N3
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem