Xiao, Junzhe; Cui, Yifan; Li, Can; Xu, Haibo; Zhai, Yizhan; Zhang, Xue; Ma, Shengming published their research in Angewandte Chemie, International Edition on December 1 ,2021. The article was titled 《Room Temperature Allenation of Terminal Alkynes with Aldehydes》.Computed Properties of C27H39ClN2 The article contains the following contents:
A gold-catalyzed room temperature allenation of terminal alkynes (ATA) with aldehydes affording 1,3-disubstituted allenes with diverse functional groups was developed by identifying a gold(I) catalyst and an amine. The practicality of this reaction had been demonstrated by a ten gram-scale synthesis and the synthetic potentials have been demonstrated via various transformations and formal total synthesis of (-)-centrolobine. Mechanistic studies revealed that the gold catalyst, the aldehyde effect, the fluoroalkyl hydroxyl solvent (TFE or HFIP) and the structure of amine were vital in this room temperature ATA reaction. In the experimental materials used by the author, we found 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride(cas: 258278-25-0Computed Properties of C27H39ClN2)
1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride(cas: 258278-25-0) has been employed in an efficient, one-pot synthesis of N-heterocyclic carbene-allylpalladium complexes.Computed Properties of C27H39ClN2In addition, it can efficiently catalyze the Suzuki-Miyaura coupling of aryl chlorides with aryl boronic acids.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem