In 2009,Truong, Anh P.; Aubele, Danielle L.; Probst, Gary D.; Neitzel, Martin L.; Semko, Chris M.; Bowers, Simeon; Dressen, Darren; Hom, Roy K.; Konradi, Andrei W.; Sham, Hing L.; Garofalo, Albert W.; Keim, Pamela S.; Wu, Jing; Dappen, Michael S.; Wong, Karina; Goldbach, Erich; Quinn, Kevin P.; Sauer, John-Michael; Brigham, Elizabeth F.; Wallace, William; Nguyen, Lan; Hemphill, Susanna S.; Bova, Michael P.; Basi, Guriqbal published 《Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitors》.Bioorganic & Medicinal Chemistry Letters published the findings.Electric Literature of C3H3BrN2 The information in the text is summarized as follows:
In this letter, a strategy is reported to design potent and metabolically stable γ-secretase inhibitors that are efficacious in reducing the cortical Aβx-40 levels in FVB mice via a single PO dose. Example synthetic routes toward a number of arylsulfonyl-substituted benzo- and heterocycle-fused pyrazolopiperidines are reported, and compound I is shown to be a metabolically stable effective γ-secretase inhibitor at sub-nanomolar levels. In the experimental materials used by the author, we found 2-Bromo-1H-imidazole(cas: 16681-56-4Electric Literature of C3H3BrN2)
2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Electric Literature of C3H3BrN2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem