Zhou, Yan; Xu, Xuexia; Wei, Yifeng; Cheng, Yu; Guo, Yu; Khudyakov, Ivan; Liu, Fuli; He, Ping; Song, Zhangyue; Li, Zhi; Gao, Yan; Ang, Ee Lui; Zhao, Huimin; Zhang, Yan; Zhao, Suwen published the artcile< A widespread pathway for substitution of adenine by diaminopurine in phage genomes>, Reference of 452-06-2, the main research area is pathway substitution adenine diaminopurine phage genome PurZ enzyme ZDNA.
DNA modifications vary in form and function but generally do not alter Watson-Crick base pairing. Diaminopurine (Z) is an exception because it completely replaces adenine and forms three hydrogen bonds with thymine in cyanophage S-2L genomic DNA. However, the biosynthesis, prevalence, and importance of Z genomes remain unexplored. Here, we report a multienzyme system that supports Z-genome synthesis. We identified dozens of globally widespread phages harboring such enzymes, and we further verified the Z genome in one of these phages, Acinetobacter phage SH-Ab 15497, by using liquid chromatog. with UV and mass spectrometry. The Z genome endows phages with evolutionary advantages for evading the attack of host restriction enzymes, and the characterization of its biosynthetic pathway enables Z-DNA production on a large scale for a diverse range of applications.
Science (Washington, DC, United States) published new progress about Bacteriophage. 452-06-2 belongs to class imidazoles-derivatives, and the molecular formula is C5H5N5, Reference of 452-06-2.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem