Sleiman, Dona; Garcia, Pierre Simon; Lagune, Marion; Loc′h, Jerome; Haouz, Ahmed; Taib, Najwa; Rothlisberger, Pascal; Gribaldo, Simonetta; Marliere, Philippe; Kaminski, Pierre Alexandre published the artcile< A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes>, Reference of 452-06-2, the main research area is purine pathway aminoadenine viral DNA genome PurZ structure phylogeny.
Cells have two purine pathways that synthesize adenine and guanine ribonucleotides from phosphoribose via inosylate. A chem. hybrid between adenine and guanine, 2-aminoadenine (Z), replaces adenine in the DNA of the cyanobacterial virus S-2L. We show that S-2L and Vibrio phage PhiVC8 encode a third purine pathway catalyzed by PurZ, a distant paralog of succinoadenylate synthase (PurA), the enzyme condensing aspartate and inosylate in the adenine pathway. PurZ condenses aspartate with deoxyguanylate into dSMP (N6-succino-2-amino-2′-deoxyadenylate), which undergoes defumarylation and phosphorylation to give dZTP (2-amino-2′-deoxyadenosine-5′-triphosphate), a substrate for the phage DNA polymerase. Crystallog. and phylogenetics analyses indicate a close relationship between phage PurZ and archaeal PurA enzymes. Our work elucidates the biocatalytic innovation that remodeled a DNA building block beyond canonical mol. biol.
Science (Washington, DC, United States) published new progress about Cyanobacteria phage S-2L. 452-06-2 belongs to class imidazoles-derivatives, and the molecular formula is C5H5N5, Reference of 452-06-2.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem