Donate, Paula B.; de Lima, Kalil Alves; Peres, Raphael S.; Almeida, Fausto; Fukada, Sandra Y.; Silva, Tarcilia A.; Nascimento, Daniele C.; Cecilio, Nerry T.; Talbot, Jhimmy; Oliveira, Rene D.; Passos, Geraldo A.; Alves-Filho, Jose Carlos; Cunha, Thiago M.; Louzada-Junior, Paulo; Liew, Foo Y.; Cunha, Fernando Q. published the artcile< Cigarette smoke induces miR-132 in Th17 cells that enhance osteoclastogenesis in inflammatory arthritis>, Electric Literature of 6823-69-4, the main research area is rheumatoid arthritis osteoclastogenesis microRNA132 Th17 cell cigarette smoke; Th17; cigarette smoke; exosomes; osteoclastogenesis; rheumatoid arthritis.
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint destruction and severe morbidity. Cigarette smoking (CS) can exacerbate the incidence and severity of RA. Although Th17 cells and the Aryl hydrocarbon receptor (AhR) have been implicated, the mechanism by which CS induces RA development remains unclear. Here, using transcriptomic anal., we show that microRNA-132 is specifically induced in Th17 cells in the presence of either AhR agonist or CS-enriched medium. miRNA-132 thus induced is packaged into extracellular vesicles produced by Th17 and acts as a proinflammatory mediator increasing osteoclastogenesis through the down-regulation of COX2. In vivo, articular knockdown of miR-132 in murine arthritis models reduces the number of osteoclasts in the joints. Clin., RA patients express higher levels of miR-132 than do healthy individuals. This increase is further elevated by cigarette smoking. Together, these results reveal a hitherto unrecognized mechanism by which CS could exacerbate RA and further advance understanding of the impact of environmental factors on the pathogenesis of chronic inflammatory diseases.
Proceedings of the National Academy of Sciences of the United States of America published new progress about Argonaute proteins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (2). 6823-69-4 belongs to class imidazoles-derivatives, and the molecular formula is C30H30Cl2N6O2, Electric Literature of 6823-69-4.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem