Hao, Xueyu; Wang, Chunyu; Wang, Yu; Li, Chunjie; Hou, Jingwei; Zhang, Feng; Kang, Chuanqing; Gao, Lianxun published the artcile< Topological conversion of human telomeric G-quadruplexes from hybrid to parallel form induced by naphthalene diimide ligands>, Name: 7H-Purin-2-amine, the main research area is naphthalene diimide G quadruplex telomere regulation; G-quadruplex; Human telomere; Naphthalene diimide; Topological conversion.
G-quadruplexes (GQs) have become promising anti-cancer therapeutic targets, which are formed by the folding of a guanine-rich repeat DNA/RNA sequence at human telomeres or oncogene promoters. Polymorphism has been observed for the folding topologies of intramol. GQs. Here we report the topol. conversion of human telomeric GQ induced by naphthalene diimide (NDI) ligands in K+ solution The ligands selectively induce metastable hybrid-type GQs to highly stable parallel-type GQ at physiol. temperature (37°C) in dilute aqueous solutions and under crowding conditions that mimic cellular bioenvironment. According to spectroscopic analyses, the topol. conversion is speculated to undergo stepwise unfolding of hybrid-type GQ through intermediate states to parallel-type GQ. The results will prompt further studies on the designs of ligands with GQ conformation regulation functions and nanotechnol. systems based on nucleic acids with dynamic regulation of GQ conformation.
International Journal of Biological Macromolecules published new progress about Animal gene, c-myc Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 452-06-2 belongs to class imidazoles-derivatives, and the molecular formula is C5H5N5, Name: 7H-Purin-2-amine.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem