《The 2-Aminoimidazoles Inhibit Mycobacterium abscessus Biofilms in a Zinc-Dependent Manner》 was written by Belardinelli, Juan M.; Li, Wei; Martin, Kevin H.; Zeiler, Michael J.; Lian, Elena; Avanzi, Charlotte; Wiersma, Crystal J.; Nguyen, Tuan Vu; Angala, Bhanupriya; de Moura, Vinicius C. N.; Jones, Victoria; Borlee, Bradley R.; Melander, Christian; Jackson, Mary. Electric Literature of C3H5N3This research focused onzinc aminoimidazole Mycobacterium abscessus smegmatis infection biofilm growth; 2-aminoimidazoles; Mycobacterium abscessus; biofilm; nontuberculous mycobacteria; zinc. The article conveys some information:
Biofilm growth is thought to be a significant obstacle to the successful treatment of Mycobacterium abscessus infections. A search for agents capable of inhibiting M. abscessus biofilms led to our interest in 2-aminoimidazoles and related scaffolds, which have proven to display antibiofilm properties against a number of Gram-neg. and Gram-pos. bacteria, including Mycobacterium tuberculosis and Mycobacterium smegmatis. The screening of a library of 30 compounds led to the identification of a compound, AB-2-29, which inhibits the formation of M. abscessus biofilms with an IC50 (the concentration required to inhibit 50% of biofilm formation) in the range of 12.5 to 25μM. Interestingly, AB-2-29 appears to chelate zinc, and its antibiofilm activity is potentiated by the addition of zinc to the culture medium. Preliminary mechanistic studies indicate that AB-2-29 acts through a distinct mechanism from those reported to date for 2-aminoimidazole compounds In addition to this study using 1H-Imidazol-2-amine, there are many other studies that have used 1H-Imidazol-2-amine(cas: 7720-39-0Electric Literature of C3H5N3) was used in this study.
1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Electric Literature of C3H5N3
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem