The author of 《ZnO Nanoparticles Catalyst in the Synthesis of Bioactive Fused Pyrimidines as Anti-breast Cancer Agents Targeting VEGFR-2》 were Dawood, Dina H.; Abbas, Eman M. H.; Farghaly, Thoraya A.; Ali, Mamdouh M.; Ibrahim, Mohammed F.. And the article was published in Medicinal Chemistry (Sharjah, United Arab Emirates) in 2019. Product Details of 934-32-7 The author mentioned the following in the article:
A new series of fused pyrimidines I (Ar = C6H5, 4-FC6H4, 4-ClC6H4 etc.), II, III using ZnO(NPs) have been synthesized and investigated for their antitumor efficiency against breast MCF7 cancer and their VEGFR- 2 inhibition properties. The proposed structures of all new fused pyrimidines are in agreement with their spectral data. It was apparent that the 2-phenylpyrazolo[1,5-a]pyrimidine derivatives II (Ar = C6H5) (IC50 = 9.12+/-177;1.16+/-181;g/mL), II (Ar = 2-pyridyl) (IC50 = 9.10+/-177;1.07+/-181;g/mL) and II (Ar = 2-furyl)(IC50 = 9.60+/-177;1.22+/-181;g/mL) exhibited equipotent antitumor activity as Tamoxifen (IC50 = 9.11+/-177;0.90+/-181;g/mL). Also, the inhibitory activity of the novel fused pyrimidine derivatives II (Ar = C6H5, 2-pyridyl, 2-furyl) on VEGFR-2 as well as Tamoxifen was determined using breast cancer cell line MCF-7. The data was obvious that 2-phenylpyrazolo[1,5-a]pyrimidine derivatives exhibited noticeable VEGFR-2 inhibitory effect with %inhibition ranging from 80-84% vs. Tamoxifen 93.5%.1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Product Details of 934-32-7) was used in this study.
1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Product Details of 934-32-7
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem