Borges-Munoz, Amaris’s team published research in Journal of Pharmaceutical and Biomedical Analysis in 2022 | CAS: 530-62-1

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.Recommanded Product: Di(1H-imidazol-1-yl)methanone

In 2022,Borges-Munoz, Amaris; Patel, Harshkumar; Tattersall, Peter published an article in Journal of Pharmaceutical and Biomedical Analysis. The title of the article was 《Derivatization and determination of residual N,N-Carbonyldiimidazole by LC for an in-process control test》.Recommanded Product: Di(1H-imidazol-1-yl)methanone The author mentioned the following in the article:

For the robust anal. of N,N-Carbonyldiimidazole (CDI), its derivatization into a more stable compound may be needed. Herein, the reaction of CDI with N-benzylmethylamine followed by LC-UV quant. anal. was explored. Reaction conditions as well as LC method feasibility were demonstrated by qualification of selectivity from other impurities and reagents, linearity across a range of 0.05-0.15%weight/weight, spike and recovery across a range of 0.05-0.15%weight/weight, reaction reproducibility with various samples, reagents and anal. chemists, and sample stability of over 24 h. Rapid and quant. derivatization of residual CDI was achieved at 0.1% weight/weight relative to the synthetic product under consideration. A fit-for-purpose limit test using a RPLC-UV method as an in-process control for the reaction completion of product, at scale, was successfully implemented and executed. In the experiment, the researchers used many compounds, for example, Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Recommanded Product: Di(1H-imidazol-1-yl)methanone)

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.Recommanded Product: Di(1H-imidazol-1-yl)methanone

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem